| 1 | Miami, United States (KMIA) | Madrid, Spain (LEMD) | 68 | Route Profile |
| 2 | New York, United States (KJFK) | Madrid, Spain (LEMD) | 34 | Route Profile |
| 3 | Dallas-fort Worth, United States (KDFW) | Madrid, Spain (LEMD) | 33 | Route Profile |
| 4 | Madrid, Spain (LEMD) | New York, United States (KJFK) | 31 | Route Profile |
| 5 | Miami, United States (KMIA) | Barcelona, Spain (LEBL) | 25 | Route Profile |
| 6 | Madrid, Spain (LEMD) | London, United Kingdom (EGLL) | 23 | Route Profile |
| 7 | Madrid, Spain (LEMD) | Miami, United States (KMIA) | 21 | Route Profile |
| 8 | London, United Kingdom (EGLL) | Tenerife, Spain (GCTS) | 17 | Route Profile |
| 9 | Madrid, Spain (LEMD) | Dallas-fort Worth, United States (KDFW) | 17 | Route Profile |
| 10 | Barcelona, Spain (LEBL) | London, United Kingdom (EGLL) | 14 | Route Profile |
| 11 | Charlotte, United States (KCLT) | Madrid, Spain (LEMD) | 12 | Route Profile |
| 12 | London, United Kingdom (EGLL) | Madrid, Spain (LEMD) | 12 | Route Profile |
| 13 | Barcelona, Spain (LEBL) | Dallas-fort Worth, United States (KDFW) | 11 | Route Profile |
| 14 | Dallas-fort Worth, United States (KDFW) | Barcelona, Spain (LEBL) | 11 | Route Profile |
| 15 | Los Angeles, United States (KLAX) | Madrid, Spain (LEMD) | 10 | Route Profile |
| 16 | Palma De Mallorca, Spain (LEPA) | London, United Kingdom (EGLL) | 10 | Route Profile |
| 17 | Madrid, Spain (LEMD) | Los Angeles, United States (KLAX) | 9 | Route Profile |
| 18 | Madrid, Spain (LEMD) | Palma De Mallorca, Spain (LEPA) | 9 | Route Profile |
| 19 | London, United Kingdom (EGLL) | Ibiza, Spain (LEIB) | 9 | Route Profile |
| 20 | Madrid, Spain (LEMD) | Zurich, Switzerland (LSZH) | 9 | Route Profile |
| 21 | London, United Kingdom (EGLL) | Malaga, Spain (LEMG) | 9 | Route Profile |
| 22 | Philadelphia, United States (KPHL) | Madrid, Spain (LEMD) | 8 | Route Profile |
| 23 | Paris, France (LFPG) | Madrid, Spain (LEMD) | 8 | Route Profile |
| 24 | Madrid, Spain (LEMD) | Bogota, Colombia (SKBO) | 8 | Route Profile |
| 25 | Madrid, Spain (LEMD) | Chicago, United States (KORD) | 8 | Route Profile |
| 26 | Tenerife, Spain (GCTS) | London, United Kingdom (EGLL) | 8 | Route Profile |
| 27 | Madrid, Spain (LEMD) | Paris, France (LFPG) | 7 | Route Profile |
| 28 | Boston, United States (KBOS) | Madrid, Spain (LEMD) | 7 | Route Profile |
| 29 | London, United Kingdom (EGLL) | Palma De Mallorca, Spain (LEPA) | 7 | Route Profile |
| 30 | Madrid, Spain (LEMD) | Boston, United States (KBOS) | 6 | Route Profile |
| 31 | Barcelona, Spain (LEBL) | Miami, United States (KMIA) | 6 | Route Profile |
| 32 | , Argentina (SAEZ) | Madrid, Spain (LEMD) | 6 | Route Profile |
| 33 | Palma De Mallorca, Spain (LEPA) | Madrid, Spain (LEMD) | 6 | Route Profile |
| 34 | Malaga, Spain (LEMG) | London, United Kingdom (EGLL) | 5 | Route Profile |
| 35 | Philadelphia, United States (KPHL) | Barcelona, Spain (LEBL) | 5 | Route Profile |
| 36 | Madrid, Spain (LEMD) | Charlotte, United States (KCLT) | 5 | Route Profile |
| 37 | Madrid, Spain (LEMD) | Tokyo, Japan (RJAA) | 5 | Route Profile |
| 38 | Barcelona, Spain (LEBL) | Philadelphia, United States (KPHL) | 5 | Route Profile |
| 39 | New York, United States (KJFK) | Barcelona, Spain (LEBL) | 5 | Route Profile |
| 40 | Barcelona, Spain (LEBL) | New York, United States (KJFK) | 5 | Route Profile |
| 41 | Tokyo, Japan (RJAA) | Madrid, Spain (LEMD) | 5 | Route Profile |
| 42 | Madrid, Spain (LEMD) | Dublin, Ireland (EIDW) | 4 | Route Profile |
| 43 | London, United Kingdom (EGLL) | Barcelona, Spain (LEBL) | 4 | Route Profile |
| 44 | Barcelona, Spain (LEBL) | Alicante, Spain (LEAL) | 4 | Route Profile |
| 45 | Bogota, Colombia (SKBO) | Madrid, Spain (LEMD) | 4 | Route Profile |
| 46 | Tenerife, Spain (GCTS) | Madrid, Spain (LEMD) | 4 | Route Profile |
| 47 | London, United Kingdom (EGKK) | Lanzerote, Spain (GCRR) | 4 | Route Profile |
| 48 | Madrid, Spain (LEMD) | Santiago, Chile (SCEL) | 4 | Route Profile |
| 49 | Charlotte, United States (KCLT) | Barcelona, Spain (LEBL) | 4 | Route Profile |
| 50 | Valencia, Spain (LEVC) | London, United Kingdom (EGLL) | 4 | Route Profile |
| 51 | Madrid, Spain (LEMD) | Tenerife, Spain (GCTS) | 4 | Route Profile |
| 52 | Lisbon, Portugal (LPPT) | Madrid, Spain (LEMD) | 3 | Route Profile |
| 53 | Madrid, Spain (LEMD) | London, United Kingdom (EGKK) | 3 | Route Profile |
| 54 | Lanzerote, Spain (GCRR) | London, United Kingdom (EGKK) | 3 | Route Profile |
| 55 | Madrid, Spain (LEMD) | Amsterdam, Netherlands (EHAM) | 3 | Route Profile |
| 56 | Madrid, Spain (LEMD) | Tenerife, Spain (GCXO) | 3 | Route Profile |
| 57 | Madrid, Spain (LEMD) | Naples, Italy (LIRN) | 3 | Route Profile |
| 58 | Chicago, United States (KORD) | Madrid, Spain (LEMD) | 3 | Route Profile |
| 59 | Munich, Germany (EDDM) | Madrid, Spain (LEMD) | 3 | Route Profile |
| 60 | Munich, Germany (EDDM) | Bilbao, Spain (LEBB) | 3 | Route Profile |
| 61 | Dublin, Ireland (EIDW) | Madrid, Spain (LEMD) | 3 | Route Profile |
| 62 | Rome, Italy (LIRF) | Madrid, Spain (LEMD) | 3 | Route Profile |
| 63 | Malaga, Spain (LEMG) | London, United Kingdom (EGKK) | 3 | Route Profile |
| 64 | Madrid, Spain (LEMD) | Hamburg, Germany (EDDH) | 3 | Route Profile |
| 65 | Madrid, Spain (LEMD) | Fuerteventura, Spain (GCFV) | 2 | Route Profile |
| 66 | London, United Kingdom (EGLL) | Valencia, Spain (LEVC) | 2 | Route Profile |
| 67 | Malaga, Spain (LEMG) | Genoa, Italy (LIMJ) | 2 | Route Profile |
| 68 | Madrid, Spain (LEMD) | Munich, Germany (EDDM) | 2 | Route Profile |
| 69 | Zurich, Switzerland (LSZH) | Madrid, Spain (LEMD) | 2 | Route Profile |
| 70 | Chicago, United States (KORD) | Barcelona, Spain (LEBL) | 2 | Route Profile |
| 71 | Tirana, Albania (LATI) | Sevilla, Spain (LEZL) | 2 | Route Profile |
| 72 | Vigo, Spain (LEVX) | Barcelona, Spain (LEBL) | 2 | Route Profile |
| 73 | Madrid, Spain (LEMD) | Brussels, Belgium (EBBR) | 2 | Route Profile |
| 74 | Bilbao, Spain (LEBB) | Barcelona, Spain (LEBL) | 2 | Route Profile |
| 75 | Tenerife, Spain (GCXO) | Madrid, Spain (LEMD) | 2 | Route Profile |
| 76 | Madrid, Spain (LEMD) | , Argentina (SAEZ) | 2 | Route Profile |
| 77 | Tenerife, Spain (GCXO) | Lisbon, Portugal (LPPT) | 2 | Route Profile |
| 78 | Madrid, Spain (LEMD) | , Portugal (LPMA) | 2 | Route Profile |
| 79 | Miami, United States (KMIA) | Ibiza, Spain (LEIB) | 2 | Route Profile |
| 80 | Tenerife, Spain (GCTS) | Miami, United States (KMIA) | 2 | Route Profile |
| 81 | Santiago, Chile (SCEL) | Madrid, Spain (LEMD) | 2 | Route Profile |
| 82 | Madrid, Spain (LEMD) | Philadelphia, United States (KPHL) | 2 | Route Profile |
| 83 | Alicante, Spain (LEAL) | Porto, Portugal (LPPR) | 2 | Route Profile |
| 84 | Los Angeles, United States (KLAX) | Barcelona, Spain (LEBL) | 2 | Route Profile |
| 85 | Amsterdam, Netherlands (EHAM) | Madrid, Spain (LEMD) | 2 | Route Profile |
| 86 | Kaliningrad, Russia (UMKK) | Barcelona, Spain (LEBL) | 2 | Route Profile |
| 87 | Barcelona, Spain (LEBL) | Madrid, Spain (LEMD) | 2 | Route Profile |
| 88 | Lisbon, Portugal (LPPT) | Palma De Mallorca, Spain (LEPA) | 2 | Route Profile |
| 89 | London, United Kingdom (EGKK) | Madrid, Spain (LEMD) | 2 | Route Profile |
| 90 | Rome, Italy (LIRA) | Barcelona, Spain (LEBL) | 2 | Route Profile |
| 91 | Madrid, Spain (LEMD) | Gran Canaria, Spain (GCLP) | 2 | Route Profile |
| 92 | Madrid, Spain (LEMD) | Lisbon, Portugal (LPPT) | 2 | Route Profile |
| 93 | Brussels, Belgium (EBBR) | Madrid, Spain (LEMD) | 2 | Route Profile |
| 94 | Ibiza, Spain (LEIB) | Madrid, Spain (LEMD) | 2 | Route Profile |
| 95 | Madrid, Spain (LEMD) | Rome, Italy (LIRF) | 2 | Route Profile |
| 96 | Barcelona, Spain (LEBL) | Lisbon, Portugal (LPPT) | 2 | Route Profile |
| 97 | Palma De Mallorca, Spain (LEPA) | Ibiza, Spain (LEIB) | 1 | Route Profile |
| 98 | Duesseldorf, Germany (EDDL) | Ibiza, Spain (LEIB) | 1 | Route Profile |
| 99 | San Antonio, United States (KSAT) | Gran Canaria, Spain (GCLP) | 1 | Route Profile |
| 100 | Newcastle, United Kingdom (EGNT) | Alicante, Spain (LEAL) | 1 | Route Profile |
| 101 | Philadelphia, United States (KPHL) | London, United Kingdom (EGLL) | 1 | Route Profile |
| 102 | Madrid, Spain (LEMD) | Oslo, Norway (ENGM) | 1 | Route Profile |
| 103 | Milano, Italy (LIMC) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 104 | Tenerife, Spain (GCXO) | Strangnas, Sweden (ESKS) | 1 | Route Profile |
| 105 | Sevilla, Spain (LEZL) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 106 | Alicante, Spain (LEAL) | Lisbon, Portugal (LPPT) | 1 | Route Profile |
| 107 | Tenerife, Spain (GCTS) | Frankfurt, Germany (EDDF) | 1 | Route Profile |
| 108 | Newark, United States (KEWR) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 109 | Los Angeles, United States (KLAX) | Ibiza, Spain (LEIB) | 1 | Route Profile |
| 110 | Sevilla, Spain (LEZL) | Ibiza, Spain (LEIB) | 1 | Route Profile |
| 111 | Halifax, Canada (CYHZ) | Zaragoza, Spain (LEZG) | 1 | Route Profile |
| 112 | Vienna, Austria (LOWW) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 113 | Porto, Portugal (LPPR) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 114 | Alicante, Spain (LEAL) | Santa Cruz De La Palma, Spain (GCLA) | 1 | Route Profile |
| 115 | Geneva, Switzerland (LSGG) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 116 | Oslo, Norway (ENGM) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 117 | Barcelona, Spain (LEBL) | Munich, Germany (EDDM) | 1 | Route Profile |
| 118 | Zurich, Switzerland (LSZH) | , Greece (LGAV) | 1 | Route Profile |
| 119 | Barcelona, Spain (LEBL) | Los Angeles, United States (KLAX) | 1 | Route Profile |
| 120 | Vigo, Spain (LEVX) | Glasgow, United Kingdom (EGPF) | 1 | Route Profile |
| 121 | Menorca, Spain (LEMH) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 122 | Barcelona, Spain (LEBL) | Chicago, United States (KORD) | 1 | Route Profile |
| 123 | Sao Paulo, Brazil (SBGR) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 124 | Naples, Italy (LIRN) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 125 | Amsterdam, Netherlands (EHAM) | Malaga, Spain (LEMG) | 1 | Route Profile |
| 126 | Amsterdam, Netherlands (EHAM) | Gran Canaria, Spain (GCLP) | 1 | Route Profile |
| 127 | Barcelona, Spain (LEBL) | Rome, Italy (LIRF) | 1 | Route Profile |
| 128 | Madrid, Spain (LEMD) | Toulouse, France (LFBO) | 1 | Route Profile |
| 129 | Vigo, Spain (LEVX) | Ibiza, Spain (LEIB) | 1 | Route Profile |
| 130 | , Ecuador (SEQM) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 131 | Tokyo, Japan (RJTT) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 132 | Naples, Italy (LIRN) | Zurich, Switzerland (LSZH) | 1 | Route Profile |
| 133 | Ibiza, Spain (LEIB) | Gibraltar, Gibraltar (LXGB) | 1 | Route Profile |
| 134 | , Qatar (OTHH) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 135 | Rome, Italy (LIRF) | Palma De Mallorca, Spain (LEPA) | 1 | Route Profile |
| 136 | Alicante, Spain (LEAL) | Faro, Portugal (LPFR) | 1 | Route Profile |
| 137 | Madrid, Spain (LEMD) | Sigonella, Italy (LICZ) | 1 | Route Profile |
| 138 | London, United Kingdom (EGKK) | Malaga, Spain (LEMG) | 1 | Route Profile |
| 139 | London, United Kingdom (EGKK) | Sevilla, Spain (LEZL) | 1 | Route Profile |
| 140 | Genoa, Italy (LIMJ) | Tenerife, Spain (GCTS) | 1 | Route Profile |
| 141 | San Diego, United States (KSAN) | Ibiza, Spain (LEIB) | 1 | Route Profile |
| 142 | Zurich, Switzerland (LSZH) | Pisa, Italy (LIRP) | 1 | Route Profile |
| 143 | Madrid, Spain (LEMD) | , Peru (SPJC) | 1 | Route Profile |
| 144 | Amsterdam, Netherlands (EHAM) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 145 | Gran Canaria, Spain (GCLP) | San Antonio, United States (KSAT) | 1 | Route Profile |
| 146 | Rome, Italy (LIRF) | , Qatar (OTHH) | 1 | Route Profile |
| 147 | Madrid, Spain (LEMD) | Manchester, United Kingdom (EGCC) | 1 | Route Profile |
| 148 | Madrid, Spain (LEMD) | Helsinki, Finland (EFHK) | 1 | Route Profile |
| 149 | Barcelona, Spain (LEBL) | Skiathos, Greece (LGSK) | 1 | Route Profile |
| 150 | Berlin, Germany (EDDB) | Vigo, Spain (LEVX) | 1 | Route Profile |
| 151 | Manchester, United Kingdom (EGCC) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 152 | Rome, Italy (LIRF) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 153 | Madrid, Spain (LEMD) | Ibiza, Spain (LEIB) | 1 | Route Profile |
| 154 | Palma De Mallorca, Spain (LEPA) | Zurich, Switzerland (LSZH) | 1 | Route Profile |
| 155 | Barcelona, Spain (LEBL) | Vigo, Spain (LEVX) | 1 | Route Profile |
| 156 | Geneva, Switzerland (LSGG) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 157 | Ibiza, Spain (LEIB) | Zurich, Switzerland (LSZH) | 1 | Route Profile |
| 158 | Rome, Italy (LIRF) | Ibiza, Spain (LEIB) | 1 | Route Profile |
| 159 | Alicante, Spain (LEAL) | Gran Canaria, Spain (GCLP) | 1 | Route Profile |
| 160 | , Peru (SPJC) | Madrid, Spain (LEMD) | 1 | Route Profile |
| 161 | Ibiza, Spain (LEIB) | London, United Kingdom (EGLL) | 1 | Route Profile |
| 162 | Palma De Mallorca, Spain (LEPA) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 163 | Palma De Mallorca, Spain (LEPA) | Sevilla, Spain (LEZL) | 1 | Route Profile |
| 164 | Madrid, Spain (LEMD) | Berlin, Germany (EDDB) | 1 | Route Profile |
| 165 | , Bermuda (TXKF) | Tenerife, Spain (GCTS) | 1 | Route Profile |
| 166 | Alicante, Spain (LEAL) | Dubrovnik, Croatia (LDDU) | 1 | Route Profile |
| 167 | Havana, Cuba (MUHA) | Tenerife, Spain (GCTS) | 1 | Route Profile |
| 168 | Madrid, Spain (LEMD) | Barcelona, Spain (LEBL) | 1 | Route Profile |
| 169 | Malaga, Spain (LEMG) | London, United Kingdom (EGSS) | 1 | Route Profile |
| 170 | Manchester, United Kingdom (EGCC) | Palma De Mallorca, Spain (LEPA) | 1 | Route Profile |
| 171 | Palma De Mallorca, Spain (LEPA) | Faro, Portugal (LPFR) | 1 | Route Profile |
| 172 | Palma De Mallorca, Spain (LEPA) | Lisbon, Portugal (LPPT) | 1 | Route Profile |
| 173 | Barcelona, Spain (LEBL) | Fez, Morocco (GMFF) | 1 | Route Profile |
| 174 | , Portugal (LPMA) | Barcelona, Spain (LEBL) | 1 | Route Profile |
